datura innoxia anti-angiogenesis properties
نویسندگان
چکیده
background and objectives: datura innoxiamilleris one of the two species of datura (solanaceae) which grow in iran. there are many reports of the biological activities of datura and in the present study the ability of datura innoxia for inhibiting angiogenesis was evaluated. methods: the methanol extract and petroleum ether, chloroform and methanol fractions of datura innoxia flowers were obtained by maceration method. the extract and fractions were further evaluated for their cytotoxicity and anti-angiogenesis properties in huv-ec-c cells through mtt and wound healing assays, respectively. results: the methanol extract and the petroleum ether, chloroform and methanol fractions were cytotoxic to huv-ec-c cells (ic50 11.25, 63.3, 8.75 and 9.27 μg/ml, respectively). the chloroform fraction demonstrated the most anti-angiogenesis activity in the wound healing assay. conclusion: evaluating the above activities of the compounds isolated from datura innoxia might be a proper follow up of the present study.
منابع مشابه
Datura innoxia anti-angiogenesis properties
Background and objectives: Datura innoxiaMilleris one of the two species of Datura (Solanaceae) which grow in Iran. There are many reports of the biological activities of Datura and in the present study the ability of Datura innoxia for inhibiting angiogenesis was evaluated. Methods: The methanol extract and petroleum ether, ...
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The kinetics of tropane alkaloids accumulation in different organs such as roots, leaves, stems, flowers and seeds of Datura innoxia was investigated by GC-MS. Twenty-six tropane alkaloids were detected. The ester derivatives of tropine (3alpha-tigloyloxytropine and 3-tigloyloxy-6-hydroxytropine) are the major compounds. Undifferentiated callus were established from the stem explants of Datura ...
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BACKGROUND Datura (family- Solanaceae), has a long history of being used as herbal medicine. These medicinal effects have been attributed to the phytochemicals present in the plant leaves and seeds, in particular alkaloids, flavonoids and phenolic compounds. The objective of this study was to investigate the methanolic leaf and seed extracts of Datura innoxia (DLP-I & DSP-I) and Datura metel (D...
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For the determination of the hyoscyamine-scopolamine content in small quantities of fresh plant tissue an HPLC assay was developed; with a sensitivity of about 20 ng alkaloid per run. Analysis of the different organs of Datura innoxia plants are in accord with the concept that hyoscyamine is synthesized in the roots, whereas transformation to scopolamine starts in these organs and proceeds in t...
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عنوان ژورنال:
research journal of pharmacognosyجلد ۴، شماره ۲، صفحات ۳۹-۴۴
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